Abstract
Rowell syndrome is a rare disease consisting of lupus erythematosus associated with erythema multiforme-like lesions. The present case study discusses the occurrence of this syndrome in a 38-year-old female who presented with erythematous scaly lesions on face, neck and back, along with the targetoid lesions on upper arms and back of the neck, with oral erosions. Laboratory investigations revealed speckled pattern of anti-nuclear antibody (ANA) with a titer of 1:640, and anti-dsDNA and anti-La (SS-B) positivity. Histology of the targetoid lesion was consistent with erythema multiforme. Significant improvement within four weeks was noted with the use of oral steroids and anti-malarials.
Highlights
Rowell syndrome is a rare disease consisting of lupus erythematosus associated with erythema multiforme-like lesions
The present case study discusses the occurrence of this syndrome in a 38-year-old female who presented with erythematous scaly lesions on face, neck and back, along with the targetoid lesions on upper arms and back of the neck, with oral erosions
Introductıon Rowell syndrome, described in 1960s, is a rare presentation of lupus erythematosus (LE) with erythema multiforme (EM)-like lesions associated with antinuclear antibody (ANA), anti-La (SS-B)/anti-Ro (SS-A) antibodies and rheumatoid factor (RF) positivity.[1, 2]
Summary
Transient plaques with central zone of normal skin or erythema, may have assciated mucosal edema Macular atypical targetoid lesions, widespread dusky erythema with blisters. Polymorphous, progressive skin lesions, severe mucosal involvement. Papillary edema with mild perivascular and interstitial infiltrate of eosinophils, lymphocytes and mast cells
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