Roving oddball paradigm elicits sensory gating, frequency sensitivity, and long-latency response in common marmosets.

Abstract

Mismatch negativity (MMN) is a candidate biomarker for neuropsychiatric disease. Understanding the extent to which it reflects cognitive deviance-detection or purely sensory processes will assist practitioners in making informed clinical interpretations. This study compares the utility of deviance-detection and sensory-processing theories for describing MMN-like auditory responses of a common marmoset monkey during roving oddball stimulation. The following exploratory analyses were performed on an existing dataset: responses during the transition and repetition sequence of the roving oddball paradigm (standard -> deviant/S1 -> S2 -> S3) were compared; long-latency potentials evoked by deviant stimuli were examined using a double-epoch waveform subtraction; effects of increasing stimulus repetitions on standard and deviant responses were analyzed; and transitions between standard and deviant stimuli were divided into ascending and descending frequency changes to explore contributions of frequency-sensitivity. An enlarged auditory response to deviant stimuli was observed. This decreased exponentially with stimulus repetition, characteristic of sensory gating. A slow positive deflection was viewed over approximately 300–800 ms after the deviant stimulus, which is more difficult to ascribe to afferent sensory mechanisms. When split into ascending and descending frequency transitions, the resulting difference waveforms were disproportionally influenced by descending frequency deviant stimuli. This asymmetry is inconsistent with the general deviance-detection theory of MMN. These findings tentatively suggest that MMN-like responses from common marmosets are predominantly influenced by rapid sensory adaptation and frequency preference of the auditory cortex, while deviance-detection may play a role in long-latency activity.