Abstract
Resin-supported [ 18F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [ 18F]FDG. “No-carrier-added” [ 18F]fluoride ion is collected on a quaternary 4-( N, N-dialkylamino)-pyridinium functionalized polystyrene anion exchange resin directly from a [ 18O]water target, dried by rinsing with acetonitrile, and then reacted with 1,3,4,6-tetra- O-acetyl-2- O-trifluoromethanesulfonyl-β- d-mannopyrannose. Acidic hydrolysis yields [ 18F]FDG in a synthesis time of 40 min with overall yields presently averaging above 50%.
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Schedule a callMore From: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
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