Abstract
Routine lumbar puncture for the early diagnosis of Alzheimer's disease. Is it safe?
Highlights
Diagnosing Alzheimer’s disease (AD) early is itself a controversial topic—not to be addressed here, as many believe that adequate therapeutics are not available for modifying the course of the disease
Numerous studies suggest that CSF biomarkers have a high potential as diagnostic tools: the measurement of the 2 key AD proteins, Amyloidbeta and Tau, is very helpful for detecting neuropathologic changes related to AD early
Specificity, and predictive values of CSF biomarkers, one may think neurologists should be sharpening their lumbar puncture needles in order to improve their diagnostic accuracy in cases of mild cognitive impairment (MCI)
Summary
Diagnosing Alzheimer’s disease (AD) early is itself a controversial topic—not to be addressed here—, as many believe that adequate therapeutics are not available for modifying the course of the disease. Numerous studies suggest that CSF biomarkers have a high potential as diagnostic tools: the measurement of the 2 key AD proteins, Amyloidbeta and Tau, is very helpful for detecting neuropathologic changes related to AD early.
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