Abstract
Route of Infection in Melioidosis
Highlights
The route of B. pseudomallei infection is at least 1 of the factors that influences disease outcome, contributing to the broad spectrum of clinical signs associated with melioidosis
Researchers use different routes of delivery of B. pseudomallei in experimental models to study the pathogenesis of the disease and the induction of host protection
The pathogenesis of B. pseudomallei NCTC 13178 infection was compared after infection by the IV, IP, SC, intranasal, and oral routes
Summary
The route of B. pseudomallei infection is at least 1 of the factors that influences disease outcome, contributing to the broad spectrum of clinical signs associated with melioidosis. Researchers use different routes of delivery of B. pseudomallei in experimental models to study the pathogenesis of the disease and the induction of host protection. Infection by different routes exposes a pathogen to different components of the host immune system and may subsequently influence disease outcome.
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