Abstract
Two novel rotenoids, (−)-13α-hydroxydeguelin and (−)-13α-hydroxytephrosin, and a new chalcone, munsericin, were isolated from the bark of Mundulea sericea, and their structures were elucidated by spectroscopic methods. Also obtained were the parent rotenoids, deguelin and tephrosin, and the known chalcone, 4-hydroxy-lonchocarpin. The rotenoids and chalcones exhibited potent inhibitory activity against phorbol ester-induced ornithine decarboxylase activity in cultured mouse 308 epidermal cells.
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