Rotavirus Vaccine Impact since Its Introduction in the National Immunization Program of Argentina.

Abstract

Rotavirus (RV) is the most common cause of childhood diarrhea. Argentina introduced RV vaccination in the National Immunization Program in January 2015. This study evaluates the impact of RV vaccine implementation on the burden of acute diarrheal disease (ADD) and RV positive cases, and hospitalizations among children in Argentina. A counterfactual time-series analysis was performed. Data on ADD (2013-2018) and RV diarrhea (2012-2018) cases in children aged < 5years were collected from the National Healthcare Surveillance System (clinical and laboratory data). Data on hospital discharges following ADD and RV diarrhea (2011-2017) were retrieved from the Health Statistics and Information Office. All data were classified by the age groups < 1year, < 2years, 2-5years. Vaccine impact was defined as the difference between the predicted time trend (simulated using 2012-2014 data) and the actual post-vaccination data (2015-2018). A significant reduction of 22.1% of notified ADD cases and 15.4% of hospital discharges following ADD among children < 2years was observed in the 3years after RV vaccine implementation. Data also showed a significant decline of 54.0% and 59.4% of notified RV cases in children < 2 and < 1years, respectively, and a reduction of 39.3% and 40.8% in RV hospital discharges for the same age groups. This study shows a significant reduction in notified ADD cases and RV cases and hospital discharges following ADD and RV cases in children < 2years after RV vaccine introduction in Argentina in 2015.