Rotavirus Vaccine and Severe Diarrhea in African Infants

Abstract

This author reply letter discusses three topics that highlight the successful results and major implications of the study for the development of a rotavirus vaccine and its clinical evaluation in developing countries. It touches on: the concept of the natural molecular evolution of rotavirus strains the potential heterotypic cross-protection offered by the monovalent G1P[8] rotavirus vaccine against strains with neither G1 nor P[8] specificity and the concept of potential interference in vaccine efficacy from antibodies in breast milk.