Abstract
The rotatory dispersions of inosine monophosphate (IMP), inosine diphosphate (IDP), and inosine triphosphate (ITP), have been determined and interpreted to indicate a folded structure of the ITP molecule, somewhat similar to that suggested for the ATP molecule. From the results obtained for the rotatory dispersion of ITP and ATP in the presence of Ca, Mg, or Zn ions, it appears that at pH 7 the combination of ATP with either Ca or Mg does not influence the optical symmetry of the molecule, but with ITP the combination with magnetium results in a product that has similar optical rotatory characteristics to ATP. These observations suggest configurational relationships that allow correlation of the physiological activities of the two molecules. The apparent alteration of the configuration of the ATP molecule in the presence of Zn ion may be used to suggest a configurational mechanism for the action of Zn ion on the 5-nucleotidase enzyme of cobra venom.
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