Abstract
BackgroundLeft ventricle rotation and torsion are fundamental components of myocardial function, and several software packages have been developed for analysis of these components. The purpose of this study was to compare the suitability of two software packages with different technical principles for analysis of rotation and torsion of the left ventricle during systole.MethodsA group of hypertrophic cardiomyopathy (HCM) patients (N = 14, age 43 ± 11 years), mutation carriers without hypertrophy (N = 10, age 34 ± 13 years), and healthy relatives (N = 12, age 43 ± 17 years) underwent a cardiovascular magnetic resonance examination, including spatial modulation of magnetization tagging sequences in basal and apical planes of the left ventricle. The tagging images were analyzed offline using a harmonic phase image analysis method with Gabor filtering and a non-rigid registration-based free-form deformation technique. Left-ventricle rotation and torsion scores were obtained from end-diastole to end-systole with both software.ResultsAnalysis was successful in all cases with both software applications. End-systolic torsion values between the study groups were not statistically different with either software. End-systolic apical rotation, end-systolic basal rotation, and end-systolic torsion were consistently higher when analyzed with non-rigid registration than with harmonic phase-based analysis (p < 0.0001). End-systolic rotation and torsion values had significant correlations between the two software (p < 0.0001), most significant in the apical plane.ConclusionsWhen comparing absolute values of rotation and torsion between different individuals, software-specific reference values are required. Harmonic phase flow with Gabor filtering and non-rigid registration-based methods can both be used reliably in the analysis of systolic rotation and torsion patterns of the left ventricle.
Highlights
Left ventricle rotation and torsion are fundamental components of myocardial function, and several software packages have been developed for analysis of these components
The goal of this work was to investigate the suitability of two available software packages and to compare the results yielded by them in three different study groups: hypertrophic cardiomyopathy (HCM) patients, mutation carriers without hypertrophy, and healthy controls
Study population The study population was selected from a previous study of myosin-binding protein C gene (MYBPC), which consisted of 32 patients carrying the Finnish founder mutation in the MYBPC gene (MYBPC3-Q1061X) with left-ventricle hypertrophy consistent with HCM phenotype, 15 subjects with the mutation and no HCM phenotype, and their 20 healthy relatives without the mutation [8]
Summary
Left ventricle rotation and torsion are fundamental components of myocardial function, and several software packages have been developed for analysis of these components. The purpose of this study was to compare the suitability of two software packages with different technical principles for analysis of rotation and torsion of the left ventricle during systole. The ventricular wall contracts, thickens, and rotates in different planes of the heart. During systole the myofibers create a rotating motion, pushing blood forward and reducing the volume of the left ventricle. When looking at the heart from the apex, this wringing motion is created by a clockwise basal rotation and a counterclockwise apical rotation [2]. Different diseases damage the heart and weaken its motion
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