Abstract
Night shift work has been associated with higher risks of breast and endometrial cancer, but few studies have evaluated associations with other reproductive cancers. We examined the association between rotating night shift work and risk of ovarian cancer during 20 years of follow-up in 181,548 women participating in two large cohort studies, the Nurses' Health Study (NHS) and NHSII. Number of years of rotating night shift work was queried in 1988 for NHS and in 1989, 1991, 1993, 2001, and 2005 for NHSII. We used Cox proportional hazards regression to model HRs and 95% CIs of ovarian cancer for each shift work category (1-2, 3-5, 6-9, 10-14, 15-19, and 20+ years). We confirmed 718 incident cases of ovarian cancer over 2,974,672 person-years of follow-up. Rotating shift work was not associated with ovarian cancer risk in either cohort individually. Combining both cohorts, compared with women without any night work, the HR for 15 to 19 years of rotating night shift work was 1.28 (95% CI: 0.84-1.94) and for 20+ years 0.80 (95% CI: 0.51-1.23). In this large prospective study, there was no association between duration of rotating night shift work and risk of ovarian cancer. Although associated with other cancers, night shift work does not appear to be associated with increased risk of ovarian cancer. However, further exploration of the association between melatonin and risk of ovarian cancer is warranted.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
