Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats.

Sadaf Jamal Gilani,Sami I Alzarea,Mohammed M Ghoneim,Muhammad Afzal,Imran Kazmi,May Nasser Bin-Jumah,Nadeem Sayyed,Sultan Alshehri,Muhammad Shahid Nadeem,Syed Sarim Imam,Fahad A Al-Abbasi

doi:10.3390/pharmaceutics14030547

Abstract

Diabetes is one of the world’s most important public health issues, impacting both public health and socioeconomic advancement; moreover, current pharmacotherapy is still insufficient. The natural flavonoid rosinidin has a long history of use in pharmaceuticals and nutritional supplements, but its role in diabetes has been unknown. The current study was intended to confirm the anti-diabetic activity of rosinidin in our laboratory setting, along with its mechanism. Streptozotocin (60 mg/kg, ip) treatment used to induce type II diabetes in rats and the test medication rosinidin was then administered orally (at doses of 10 mg/kg and 20 mg/kg) for biochemical and histopathological analysis. Treatment with rosinidin reduced negative consequences of diabetes. Rosinidin exerted a protective effect on a number of characteristics, including anti-diabetic responses (lower blood glucose, higher serum insulin and improved pancreatic function) and molecular mechanisms (favorable effects on lipid profiles, total protein, albumin, liver glycogen, proinflammatory cytokine, antioxidant and oxidative stress markers, AST, ALT and urea). Furthermore, the improved pancreatic architecture observed in tissues substantiated the favourable actions of rosinidin in STZ-induced diabetic rats.

Highlights

The diabetes was proven by reduced body weight in conjunction with biochemical indicator changes
The problems associated with insulin and oral hypoglycemic medications have sparked interest in finding natural substances with anti-diabetic properties
The goal of this research study was to learn more about the processes by which rosinidin protects against type II diabetes mellitus, in order to offer fresh light on type II diabetes mellitus prevention using flavonoid-based alternatives

Summary

Introduction

Diabetes mellitus is one of the world’s biggest public health problems, impacting both public health and socioeconomic advancement. It has a devastating economic impact, accounting for approximately 10% of global health expenditures [1]. Diabetes mellitus is a long-lasting endocrine ailment triggered by abnormalities in the production of insulin by pancreatic cells and its actions in outlying tissues, resulting in metabolic abnormalities [2]. Despite substantial advancements in diabetes management over the last decades, patient outcomes from diabetes medications are still far from ideal. Despite substantial advancements in diabetes management over the last decades, patient outcomes from diabetes medications are still far from ideal. 4.0/).

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