, , Roshaan , ,

Abstract

Background: Microbial resistance to various drugs is a significant challenge in treating infectious diseases, necessitating the development of new drugs. Pyrimidine, with diverse biological effects, is an effective component in antimicrobial drugs. Despite significant progress over the last decade in studying pyrimidine as an antimicrobial agent, a bibliometric analysis in this area is lacking. This analysis aims to fill that gap and provide insights into the field's evolution. Methods: A comprehensive examination of the available literature published between 2015 and 2023 on pyrimidine derivatives as antimicrobial agents was done across the Scopus database. Microsoft Excel 365 was employed to analyze the quantitative variables, such as publications and citation counts, for the authors, institutions, countries, and journals. Furthermore, the network visualization and analysis of co-authorship, co-occurrence, and co-citation among countries, institutions, authors, and keywords were facilitated by VOSviewer. Results: A total of 934 articles were selected for the study. The years 2019 and 2022 exhibited the highest volume of published papers on pyrimidine derivatives as antimicrobial agents between 2015 and 2023, with 125 publications each. A total of 53 countries contributed to the topic, with India leading in publications, followed by Egypt, China, Saudi Arabia, and the United States. Among journals, the Journal of Heterocyclic Chemistry had the highest number of publications (n = 50), followed by the European Journal of Medicinal Chemistry with 37 publications. Conclusion: The findings offer crucial insights for researchers in choosing specific compounds for future studies, highlighting the importance of bibliometric analysis in advancing pyrimidine antimicrobial research.