Abstract
Peripheral blood lymphocytes from 30 patients with chronic lymphocytic leukemia (CLL) and 18 patients with malignant non-Hodgkin's lymphomas in leukemic phase were studied for rosette-formation with neuraminidase-treated mouse erythrocytes. The proportion of rosette-forming cells in CLL was significantly higher (p < 0.001) than in 12 cases of lymphoplasmacytoid malignant lymphoma (LPL). Our results suggest that this test may be a helpful method in the differentiation of CLL from leukemic LPL, which usually can not be distinguished by morphological criteria alone.
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