Abstract
Objective: This study aim to analyze the effect of the roselle calyx ethanol extract on oral mucosal wound healing.Methods: Male Sprague Dawley rats (3 month, 150 g) were housed under standard temperature conditions (20–22°C). Punch biopsy wounds were inflicted on the inferior labial mucosal membrane of rats. All treatments (normal saline; 0.1% triamcinolone acetonide; and 3.75%, 7.5%, and 15% roselle calyx ethanol extract) were applied 2 times daily. Wounded areas were observed after 8 days of treatment. The specimen of the wounded area was prepared and microscopic slides were analyzed under a light microscope.Results: The histological features of the groups treated with TA and 7.5% roselle calyx ethanol extract showed a similar formation of the epidermis layer and no lymphocytic infiltration of the lamina propria.Conclusion: The application of 7.5% roselle calyx ethanol extract could stimulate oral mucosal wound healing.
Highlights
The oral mucosal membrane is prone to developing wounds originating from trauma or immunological processes [1]
The wound diameters of Group II rats treated with 3.75%, 7.5%, and 15% roselle calyx ethanol extracts differed significantly (p
Treatments with 7.5% roselle calyx ethanol extracts and with TA resulted in nearly similar wound diameters at day 8
Summary
The oral mucosal membrane is prone to developing wounds originating from trauma or immunological processes [1]. Cheek mucosal membranes are frequently wounded, especially as a result of brushing teeth, accidental cheek bites, or occlusal disharmony [2]. Such wounds in the mucosal membrane are called ulcers, or aphthous ulcers, which manifest as painful lesions that range from the size of a pinhead to several centimeters in diameter; these usually cause pain and discomfort during eating and speaking [2,3]. The healing process is influenced by several factors such as infection, nutrition, drugs, and hormones; the type, depth, and sites of wounds and certain disease conditions may impact healing [4]. Remodeling of the dermis requires collagen, antioxidants, and both matrix-producing proteins and protease enzymes, which are essential for initiating the remodeling of tissues during wound recovery [6,7,8]
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