Abstract
(Anesth Analg. 2020;130:321–331) Epidural-related maternal fever (ERMF), which is associated with perinatal mortality and neonatal morbidity, occurs in up to 20% of laboring women receiving epidural analgesia. Epidural analgesia has been suspected to cause maternal fever by signaling the release of proinflammatory endogenous pyrogens. In previous studies, antibiotics did not decrease the incidence of ERMF. This study compared the effects on inflammation of ropivacaine with lidocaine in human umbilical vein endothelial cells (HUVECs) and human first trimester placental trophoblasts (TBs). The study also investigated the impact of dexamethasone, an anti-inflammatory corticosteroid.
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