Room-Temperature Direct Arylation of Anilides under External Oxidant-Free Conditions Using CO2-Derived Dimethyl Carbonate (DMC) as a ′Green′ Solvent

Abstract

Here, an efficient catalytic protocol for direct C−H bond arylation of anilides under base- and external oxidant-free conditions is reported. This reaction proceeds readily at room temperature using CO2-derived dimethyl carbonate (DMC) as a ′green′ solvent under visible-light dual catalysis. Later, application of our strategy for the gram-scale synthesis of Boscalid has been successfully shown. An unprecedented unsymmetrical bis-arylation of anilides is also demonstrated under mild, redox-neutral conditions.