Abstract

An efficient and facile synthesis of hydrazones, bis(indolyl)methanes and bis(4-hydroxycoumarin)methanes is facilitated by room temperature ionic liquid choline chloride–oxalic acid (ChCl:Ox). ChCl:Ox (10mol%) efficiently catalyzes condensation of aldehydes with phenylhydrazine giving corresponding hydrazones in high yield (92–96%) within short reaction time of 3–5min. Electrophilic cyclization reaction of indole and 4-hydroxy coumarin with aromatic aldehyde was effectively promoted by 30mol% of ChCl:Ox giving corresponding bis(indolyl)arylmethanes and bis (4-hydroxycoumarin)methanes in good yield at room temperature. Procedure is very simple, solvent free and completely eliminates use of toxic acid catalyst. ChCl:Ox is biodegradable, can be recycled and reused without the loss of efficiency with respect to yield.

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