Abstract
Immune thrombocytopenia is characterized by reduced platelet count. This condition occurs in both adults and children. The most common form of thrombocytopenia is primary ITP and autoantibodies are involved in its development. In this study, our patient was a pregnant woman with ITP who showed refractory to prednisolone and splenectomy as first and second line treatment, respectively, but the response to treatment with Romiplostim and platelet count was favorable, and delivery was reported without fetal complications.
Highlights
Immune thrombocytopenia (ITP), formerly known as idiopathic thrombocytopenic purpura, is an autoimmune disease described by a severe reduction in peripheral blood platelets [1]
We have reported a pregnant woman with ITP who was refractory to prednisolone and splenectomy but responded positively to the treatment with Romiplostim
Romiplostim Advantages Response rates ≈ 95% Approved by the FDA for patients with chronic ITP Increases quality of life Decreases the need for rescue treatments Decreases bleeding complications
Summary
Immune thrombocytopenia (ITP), formerly known as idiopathic thrombocytopenic purpura, is an autoimmune disease described by a severe reduction in peripheral blood platelets [1]. Types of thrombocytopenia include primary and secondary ITP. Primary ITP is due to the autoimmune destruction of platelets, which include 80% of the patients. For patients with chronic ITP, there are several treatments that includes corticosteroids, immunoglobulin, splenectomy, and thrombopoietin receptor agonists (TPO-RAs). The rationale for selecting TPO-RAs in the treatment of refractory ITP is that the level of thrombopoietin (TPO) is abnormal or low in the patients. The response rates of ITP patients to IVIG and corticosteroids have been reported to be less than 40% [8], while for TPO-RAs, the response rate is reported 59-88% [9].
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