Roles played by depressing synapses in neural circuits

Abstract

Event Abstract Back to Event Roles played by depressing synapses in neural circuits Joanna Jędrzejewska-Szmek1* and Jarosław Żygierewicz2 1 University of Warsaw Faculty of Physics, Poland 2 University of Warsaw Faculty of Physics, Poland Synapses exhibiting short-term synaptic depression can be found in different locations in neural circuits [1], e.g. pyramid-pyramid and interneuron-pyramid connections. Based on these findings, two Wilson-Cowan type models with depressing synapses were constructed, following formalism presented in [2]. First one comprised a depressing positive feedback, the second one comprised a depressing negative feedback (synapse is between the inhibitory and excitatory population). The models' parameters were provided by [1,3]. Both models generated oscillatory signals as predicted by [2,3]. In case of both models a regime exists with high frequency oscillations (higher than 80 Hz) and high amplitude of oscillations corresponding to 'high-gamma' characteristics [4]. The model with depressing positive feedback showed three regimes: 1) oscillations in the theta band almost independent of external input of the excitatory population, 2) high-frequency oscillations with an envelope frequency in the theta band. In the third regime we observed oscillations in theta and 'high-gamma band'. An increase of the external input can abruptly change the oscillation frequency from the theta band to 'high-gamma'. Excitatory population firing rate is shown in the Figure below. One can see, that generated activity is similar to the theta/gamma oscillations [5] linked to short-term memory [5,6]. Short-term synaptic depression plays important role in generation of not only slow oscillations activity [3] and theta waves, but also higher frequency phenomena such as 'high-gamma'. It might also serve as a basis for coupling between the high- and low-frequency bands of ongoing electrical activity in the human brain [5,6,7]. [1] Bannister AP, Thomson AM. Cerebral Cortex 2007 [2] Tsodyks MV, Pawelzik K, Markram H. Neural Computation 1998 [3] Melamed O, Barak O, Silberberg G, Markram H, Tsodyks M. Journal of Computational Neuroscience 2008 [4] Ray S, Maunsell JHR. PloS Biology 2011 [5] Lisman J. Hippocampus 2005 [6] Lisman J, Idiart MA. Science 1995 [7] Canolty RT, Edwards E, Dalal SS, Soltani M, Nagarajan SS, Kirsch HE, Berger MS, Barbaro NM, Knight RT. Science 2006 Figure 1 Keywords: computational neuroscience, neural circuits, Synapses, electrical activity, human brain Conference: 5th INCF Congress of Neuroinformatics, Munich, Germany, 10 Sep - 12 Sep, 2012. Presentation Type: Poster Topic: Neuroinformatics Citation: Jędrzejewska-Szmek J and Żygierewicz J (2014). Roles played by depressing synapses in neural circuits. Front. Neuroinform. Conference Abstract: 5th INCF Congress of Neuroinformatics. doi: 10.3389/conf.fninf.2014.08.00020 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 21 Mar 2013; Published Online: 27 Feb 2014. * Correspondence: Dr. Joanna Jędrzejewska-Szmek, University of Warsaw Faculty of Physics, Warszawa, Poland, asia@in.waw.pl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Joanna Jędrzejewska-Szmek Jarosław Żygierewicz Google Joanna Jędrzejewska-Szmek Jarosław Żygierewicz Google Scholar Joanna Jędrzejewska-Szmek Jarosław Żygierewicz PubMed Joanna Jędrzejewska-Szmek Jarosław Żygierewicz Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.