Abstract
Ubiquitin-conjugating enzyme 2C (UBE2C) is involved in cell cycle progression, mitosis regulation and targeted degradation of short-lived proteins. UBE2C is the cancer-related ubiquitin-conjugating enzyme, which is significantly higher in breast cancer tissues compared to the adjacent normal tissue. The abnormal expression of UBE2C participates in the process of occurrence, development and metastasis of breast cancer by the regulation of cell cycle progression, C-erbB-2, cell apoptosis factors and metastasis related genes. It will provide reference for the diagnosis and prognosis of breast cancer. Key words: Cell cycle; Breast neoplasms; Ubiquitin-conjugating enzyme 2C
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