Roles of T-helper 17(Th17) cells in the pathogenesis of systemic lupus erythematosus

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disorder. Abnormal immune responses mediated by T-helper cells and their cytokines play a role in the pathogenesis of SLE. By secreting interleukin (IL)-17 and IL-21, Th17 cells can trigger inflammation and cause target organ damage, participate in the regulation of both T and B cells, and promote the production of autoantibodies. Evidences are accumulated that Th17 cells play an important role in the initiation and progression of SLE. This paper describes Th17 cell biological features and relationship with SLE. Key words: Lupus erythematosus, systemic; Th17 cells