Abstract
逆向囊泡转运复合物Retromer主要负责介导货物蛋白从内体向反式高尔基体或细胞表面逆向转运, 是细胞内囊泡转运分选系统的重要成员. Retromer复合物主要含有两个亚复合体: 货物选择复合 体VPS26-VPS29-VPS35和膜结合复合体SNX-BAR. 本文着重综述了Retromer复合物和SNX蛋白家族参与 囊泡转运过程的分子机制以及它们在发育中对Wnt信号的调控作用; 并讨论了Retromer复合物在细胞极性 形成、细胞凋亡、神经元信号传递中的重要作用; 以及该复合物与帕金森和阿尔茨海默病等退行性疾病之间的关系.
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