Abstract
In recent years, much progress has been made in elucidating the functional roles of plant glycine-rich RNA-binding proteins (GR-RBPs) during development and stress responses. Canonical GR-RBPs contain an RNA recognition motif (RRM) or a cold-shock domain (CSD) at the N-terminus and a glycine-rich domain at the C-terminus, which have been associated with several different RNA processes, such as alternative splicing, mRNA export and RNA editing. However, many aspects of GR-RBP function, the targeting of their RNAs, interacting proteins and the consequences of the RNA target process are not well understood. Here, we discuss recent findings in the field, newly defined roles for GR-RBPs and the actions of GR-RBPs on target RNA metabolism.
Highlights
IntroductionAn increasing occurrence of extreme weather events (heatwaves, drought, torrential rains), together with dire projections regarding climate change, makes the improvement of crop resilience to environmental and pathogen stress of paramount importance for feeding a growing global population [1]
An increasing occurrence of extreme weather events, together with dire projections regarding climate change, makes the improvement of crop resilience to environmental and pathogen stress of paramount importance for feeding a growing global population [1]
FATTY ACID DESATURASE 2 (FAD2), which has been shown to contribute to salt tolerance, was identified as a target RNA for AtGRP7 by individual nucleotide resolution crosslinking and immunoprecipitation (iCLIP), and it was reported that overexpression of AtGRP7 in A. thaliana had a negative effect on germination and seedling growth under salt stress conditions due to FAD2 downregulation [34]
Summary
An increasing occurrence of extreme weather events (heatwaves, drought, torrential rains), together with dire projections regarding climate change, makes the improvement of crop resilience to environmental and pathogen stress of paramount importance for feeding a growing global population [1] To this end, a greater understanding of molecular mechanisms involving stress tolerance genes is essential for genetic improvement of crop species. The biological functions of GR-RBPs have been described in various species, with special focus on regulation of gene expression, and RBPs are known to be involved in RNA mechanisms and several defense pathways; despite this, little is known about their structure/function relationship To our knowledge, this is the first compilation of available data regarding the participation of plant GR-RBPs in various biological functions, such as development and stress responses, using different key technologies
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