Abstract
Cervical cancer is a major health problem worldwide and is the most frequent cause of cancer in women in India. Early detection and affordable drugs with clinical efficacy have to go hand-in-hand in order to comprehensibly address this serious health challenge. Plant-based drugs with potent anticancer effects should add to the efforts to find a cheap drug with limited clinical side effects. Keeping this very purpose in mind, an attempt has been made in this review to explore the potential of plant extracts or constituents known to exhibit antitumorigenic activity or exert cytotoxic effect in human cervical carcinoma cells. Alkaloids such as those isolated from C. vincetoxicum and T. Tanakae, naucleaorals A and B, isolated from the roots of N. orientalis, (6aR)-normecambroline, isolated from the bark of N. dealbata appear promising in different human cervical carcinoma cells with the IC50 of 4.0-8 μg/mL. However, other compounds such as rhinacanthone and neolignans isolated from different plants are not far behind and kill cervical cancer cells at a very low concentrations. Among plant extracts or its constituents that enhance the effect of known anticancer drugs, noni, derived from the plant M. citrifolia perhaps is the best candidate. The cytotoxic potency and apoptotic index of cisplatin was found to significantly enhanced in combination with noni in different human cervical carcinoma cells and it therefore holds significance as promising herbal-based anticancer agent. However, efficacy needs to be further investigated in various cervical cell lines and more importantly, in in vivo cervical cancer models for possible use as an alternative and safe anticancer drug.
Highlights
Cervical cancers, like any other cancers, continue to be pose serious health problem globally
Plant-based drugs with potent anticancer effects should add to the efforts to find a cheap drug with limited clinical side effects. Keeping this very purpose in mind, an attempt has been made in this review to explore the potential of plant extracts or constituents known to exhibit antitumorigenic activity or exert cytotoxic effect in human cervical carcinoma cells
Alkaloids such as those isolated from C. vincetoxicum and T
Summary
Like any other cancers, continue to be pose serious health problem globally. It was proposed in this study that the cytotoxic effect of ellagic acid was is through up-regulation of oxidative stress Compounds such as 6-Methoxygossypol and 6, 6’-dimethoxygossypol, isolated from the root tissue of cotton plant, belongs to the polyphenolic group, and have been shown to exhibit dose-dependent growth inhibition against another cervical cancer cell line-SiHa (Wang et al, 2008). It was reported that rhinacanthone induced apoptotic cell death through multiple pathways such as cell cycle arrest in G2/M phase, modulation Bcl-2 family, downregulation of surviving and up-regulation of apoptosis inducing factor (AIF protein) as well as activations of mitochondria mediated caspase-dependent and caspaseindependent signalling pathways Azaanthraquinone compound such as laoticuzanone A, isolated from the stems of Goniothalamus laoticus have been shown to exhibit cytotoxicity against HeLa cells with IC50 values of 0.50 μg/ml (Tip-Pyang et al, 2010). The high Six 1-glyceryl ethers cytotoxic activity in crude DCM extracts corroborated the Ceratodictyols A and B and mixtures of ceratodictyols earlier observation in the same study on other plant that C and D and ceratodictyols E and F, isolated from the the bioactive components have a moderate to low polarity. red alga-sponge assemblage Ceratodictyon spongiosum/
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
