Roles of PI3k pan-inhibitors and PI3k-d inhibitors in allergic lung inflammation: systematic review and a meta-analysis

Abstract

Meta-analysis can be applied to study the effectiveness of the summary estimates for experimental papers, producing objective and unbiased results. We investigate the effects of phosphoinositide-3-kinase on the inflammatory profile in allergic mouse models, which are currently under development in signal transduction materials. PubMed, EMBASE and Web of Science databases were searched for relevant literature using the search term inhibitor and allergy or asthma. Cochrane Review Manager and R were used for handling continuous variables. The primary outcomes of the inflammatory profile were divided into cell count and inflammatory cytokines. We used a random effects model to draw a forest plot. Through the database search and subsequent selection, 17 articles were identified. Regarding the cell count, both the PI3k pan-inhibitors and PI3k-δ inhibitors effectively reduced the total cell count, eosinophils, neutrophils and lymphocytes. In contrast to PI3k-δ inhibitors, PI3k pan-inhibitors effectively reduced macrophages. Regarding the inflammatory cytokines, PI3k pan-inhibitors and PI3k-δ inhibitors effectively reduced total IgE, IL-4, IL-5, IL-13, TNF-α, IL-1β, VEGF and have no effect on IL-6. Compared to the PI3k pan-inhibitors, which block all pathways, selective PI3k-δ inhibitors are expected to be relatively less toxic. Regarding the efficacy, PI3k-δ inhibitors have at least the same or better efficacy than PI3k pan-inhibitors in effector cells and inflammatory mediators.