Abstract
Parkinson's disease is a neurodegenerative disorder associated with loss of dopaminergic neurons in substantianigra caused by severe neuro-degeneration, which is the second most common neurodegenerative disorder after Alzheimer’s disease.Parkinson's disease has a high prevalence of psychiatric comorbidity including depression. The neuropsychiatric symptoms are common in Parkinson's disease and may precede onset of motor symptoms. Increasing interest is often addressed to the selective targeting of some of metabotropic glutamate receptors that inhibit the transmitter release at synapses in the basal ganglia. The metabotropic glutamate receptors may be coupled to the phosphatidylinositol-3-kinase (PI3K), AKT, and PTEN pathways, whichplay a central role in cell survival. A better understanding of the molecular connections in the PI3K pathways could uncover new targets for drug development in Parkinson's disease.
Highlights
Parkinson’s disease (PD) is a movement disorder represented by the production of tremor, rigidity, and bradykinesia [1]
The major disturbances in PD patients are due to the loss of dopaminergic neurons in the substantianigra which results in the alterations of striatal synaptic transmission in the basal ganglia [5]
The dopaminergic neurons are susceptible to inflammations and oxidative stresses due to the environment of the dopamine biosynthetic pathways and the low mitochondrial reserve compared to other neuronal populations [7,8]
Summary
Parkinson’s disease (PD) is a movement disorder represented by the production of tremor, rigidity, and bradykinesia [1]. Metabotropic glutamate (mGlu) receptors have been shown to play a key role in the striatal function both in physiological and in pathological conditions affecting this neuronal area [6]. The mGlu receptors modulate synaptic transmission in the central nervous system and represent promising therapeutic targets for symptomatic treatment of PD. The mGlu receptors regulate PI3K and AKT signaling pathway (Fig. 1), which plays a crucial role in the mechanisms of PD [12]. Activation of the mGlu receptors/AKT signaling pathway seems to play a crucial role in the mechanisms of PD pathogenesis. This paper provides a concise overview of the potential cellular functions of the mGlu receptors and the AKT signaling, and the molecular interplay in the processes underlying the neurodegenerative disorders
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
