Roles of osteocytes in mechanosensation

Abstract

Objective To summarize the roles of osteocytes in bone mechanosensation. Literature resource and selection Related papers and reviews that published at home and abroad. Literature quotation Fifty-seven papers were cited. Literature synthesis Such subjects as biological characteristics of osteocytes, differences between osteocytes and osteoblasts, the roles of special structures of osteocytes in mechanotransduction, the mechanosensors of bone, signal transmission during mechanosensation, the relationship of osteocytes and weightless caused bone loss were reviewed and summarized. Conclusion Osteocytes are the mechanosensors in bone. When mechanical stimuli are sensed, osteocytes regulate the functions of osteoblasts and osteoclasts by the cellular network transmission in the process of bone remodeling. Key words: Osteocytes ;  Osteoblasts ;  Osteoclasts ;  Mechanotransduction,cellular ;  Review literature ;