Abstract
During the formation of blood vessels, Id1, a member of the helix-loop-helix (HLH) family, and TAL1/SCL, a basic HLH (bHLH) transcription factor, play important roles in the activation of endothelial cells. Recent reports revealed that E2-2, another bHLH transcription factor, inhibits angiogenesis in vitro and in vivo by suppressing the expression of vascular endothelial growth factor receptor 2 (VEGFR2). Id1 and TAL1/SCL dimerize with E2-2 and relieve the E2-2-mediated down-regulation of VEGFR2 expression, leading to the activation of endothelial cells. These findings reveal a novel interplay between HLH transcription factors that regulate angiogenesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
