Abstract
The morbidity and mortality of myocardial ischemia-reperfusion injury (MIRI) haveincreased in modern society. Noncoding RNAs (ncRNAs), including lncRNAs, circRNAs, piRNAsand miRNAs, have been reported in a varietyof studies to be involved in pathological initiation and developments of MIRI. Hencethis review focuseson the current research regarding these ncRNAs in MIRI. We comprehensively introducethe important features of lncRNAs, circRNAs, piRNA and miRNAs and then summarizethe published studiesof ncRNAs in MIRI. A clarification of lncRNA-miRNA-mRNA, lncRNA-transcription factor-mRNA and circRNA-miRNA-mRNA axes in MIRI follows, to further elucidate the crucial roles of ncRNAs in MIRI. Bioinformatics analysis hasrevealed the biological correlation of mRNAs with MIRI. We provide a comprehensive perspective for the roles of these ncRNAs and their related networks in MIRI, providing atheoretical basis for preclinical and clinical studies on ncRNA-based gene therapy for MIRI treatment.
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