Abstract
Metastasis remains to be a huge challenge in cancer therapy. The mechanism underlying cervical cancer metastasis is not well understood and needs to be elucidated. Recent studies have highlighted the diverse roles of non-coding RNAs in cancer progression and metastasis. Increasing numbers of miRNAs, lncRNAs and circRNAs are found to be dysregulated in cervical cancer, associated with metastasis. They have been shown to regulate metastasis through regulating metastasis-related genes, epithelial-mesenchymal transition, signaling pathways and interactions with tumor microenvironment. Moreover, miRNAs can interact with lncRNAs and circRNAs respectively during this complex process. Herein, we review literatures up to date involving non-coding RNAs in cervical cancer metastasis, mainly focus on the underlying mechanisms and highlight the interaction network between miRNAs and lncRNAs, as well as circRNAs. Finally, we discuss the therapeutic prospects.
Highlights
Cervical cancer is a common gynecological cancer which ranks fourth for both incidence and mortality in women worldwide [1]
A recent study based on bioinformatic analysis found that miR218-5p could inhibit cervical cancer cell metastasis via targeting LYN/NF-kB signaling pathway [34]
LncRNA Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1) was revealed to suppress metastasis in cervical cancer by sponging miR-93-3p and upregulating PEG3 [85]. Another cancer-related lncRNA DANCR was found to act as a competing endogenous RNAs (ceRNAs) for miR-665 and promote metastasis of cervical cancer through the ERK/SMAD pathway [86]
Summary
Department of Obstetrics and Gynecology, Affiliated Haikou Hospital, Xiangya Medical College of Central South University, Haikou, China Edited by: Alberto Farolfi, Romagnolo Scientific Institute for the Study and Treatment of Tumors (IRCCS), Italy Reviewed by: Bei Pan, Nanjing Medical University, China Huazhang Wu, Bengbu Medical College, China
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