Abstract
Microbial metabolites, including primary and secondary metabolites, play important roles in bacteriophage-host interactions. The primary metabolites are involved in microbial basic metabolisms for energy production and cell component production, while the secondary metabolites are produced from the primary metabolites. Although the secondary metabolites are not necessary for normal growth of microbes, they are vital for interactions with other microorganisms and environment. The biosynthesis of secondary metabolites is controlled by a lot of factors, such as pathway-specific and global regulator, signal transduction pathways, and epigenetic factors. Bacteriophage infection can alter its host metabolism, and the metabolites from bacteriophage-microbe interactions play very important roles in evolution, ecology, and pharmaceutical implications. The bacteriophage-encoded auxiliary metabolic genes can remodel the host metabolic networks and expand the host metabolism capabilities. On the other hand, the hosts have developed a variety of metabolic strategies to sense and counteract virus infection.
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