Abstract
In mice pre-induced MT by the Zn injection (10 mg/kg, s. c.), the mortality of the mice injected with the lethal dose of Cd (10 mg/kg, s. c.) decreased more significantly (p<0.01) than that of the control group. But, this protective effect of the preinjection of Zn was not observed in the case of increasing dose of Cd to 15 or 20 mg/kg. However, induced high concentration of MT by the pre-injection of Zn (50 mg/kg, s. c.), the mortality of mice, which were injected s. c. with Cd at the dose of 20 or 30 mg/kg, decreased more significantly than that of the control group (p<0.05 or 0.01). These results indicate that high concentration of MT is significant to prevent acute Cd toxicity.
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