Abstract
We investigated whether pretreatment with an interleukin-1 receptor antagonist (IL-1RA) is capable of inhibiting immobilization stress (IS) -induced elevations of hypothalamic norepinephrine (NE) and the levels of their metabolites as well as the plasma adrenocorticotropic hormone (ACTH) . IL-1 RA was administered directly into the anterior hypothalamus, and monoamines were determined using a microdialysis technique and an HPLC system. IL-1 RA (2μg) significantly inhibited IS-induced increases in hypothalamic NE level. In addition, IL-1RA (2μg) also inhibited the IS-induced elevation of plasma ACTH levels. In summary, these results suggest that hypothalamic interleukin-1 (IL-1) plays a role in the regulation of IS-induced responses including elevated monoamine release in the hypothalamus and activation of the hypothalamo-pituitary-adrenal axis.
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