Abstract
Gram-positive microorganisms comprise one of the leading pathogenic microorganisms in public health, including several ‘Superbugs’ such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, which have posed a dilemma for the treatment of infectious diseases caused by Gram-positive bacteria and will consequently result in an increasing number of clinical failures. Integrons have been established as a significant resistance determinant and shown to contribute to the multiresistance of microorganisms; however, its role in antimicrobial resistance in Gram-positive microorganisms still remains unclear and somehow neglected. In the last decade, integron surveillance has been conducted for various clinical microorganisms in Guangzhou, China, and based on this study this review aims at summarizing the occurrence and prevalance of integrons and their role in the antimicrobial resistance of Gram-positive microorganisms.
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