Abstract
Histamine plays an important role in broncho constriction mediated by histamine receptors which provoke bronchial asthma attack. In this study, we measured H 1 and H 2 receptors in the guinea pig lung membrane fraction and obtained the following results. The maximum binding ( B max) of H 1 receptors in the guinea pig lung membrane fraction was significantly higher in the OA-sensitized group than that in the non-sensitized group, but affinity ( K d) did not differ between the groups. Otherwise, the maximum binding ( B max) of H 2 receptors in the guinea pig lung membrane fraction was significantly lower in the OA-sensitized group than that in the non-sensitized group. But affinity ( K d) did not differ between the groups. These findings suggest a close association of Histamine receptors both H 1 and H 2 in the pathology of asthma.
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