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Abstract
Histamine is an important mediator in inflammatory responses, and histamine H4 receptor is a newly discovered histamine receptor mainly expressed on immune organs and cells. Recent researches have indicated that histamine H4 receptor participates in immunoregulation, pruritus and epidermal proliferation in the pathogenesis of atopic dermatitis. Specific antagonists of histamine H4 receptor can affect the development and attenuate clinical symptoms of atopic dermatitis, such as eczematoid dermatitis and intractable itch, by exerting antiinflammatory, immunoregulatory and antipruritic effects via T-lymphocytes, antigen-presenting cells and keratinocytes. Hence, histamine H4 receptor antagonists are expected to be a novel and effective approach to the treatment of atopic dermatitis. Key words: Dermatitis, atopic; Histamine; Receptors, histamine H4; Hypersensitivity; Pruritus
Published Version
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