Abstract

Tumor induced osteomalacia(TIO) is an acquired hypophosphatemie syndrome caused y tumors.Experimental evidence suggests that the biochemical and skeletal defects are caused by humeral factors(phosphatonins)from the tumor.The potential candidates for phosphatonins,such as fibroblast growth factor-23(FGF-23),matrix extracellular phosphoglyeoprotein(MEPE)and secreted frizzled related protein 4(sFRP4)are characterized by impaired renal tubular reabsorption of phosphate,and inhibited l,α hydroxylase.They induce low levels of serum phosphate and 1,25-dihydroxyvitamin D3,therefore,play important roles in the pathogenesis of TIO. Key words: Tumor induced osteomalacia; Fibroblast growth factor-23; Matrix extracellular phosphoglycoprotein; Secreted frizzled related protein 4

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