Abstract
1. Two kinds of slow postsynaptic potentials can be elicitable in the rabbit superior cervical ganglion: a dopaminergic hyperpolarizing (slow IPSP) one and a muscarinic depolarizing (slow EPSP) one, respectively. 2. Cyclic AMP may not be involved in the generation of slow IPSP, whereas it certainly mediates the dopamine-induced enduring modulatory enhancement of the slow EPSP response. 3. Cyclic GMP appears to mediate at least one of the components in the mechanism underlying the slow EPSP by generating a depolarization with no change in membrane conductance. 4. Cyclic GMP does additionally regulate the dopamine (or cyclic AMP)-induced modulatory enhancement of the slow EPSP by antagonizing it in a uniquely time-dependent fashion.
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