Abstract
Inflammatory factors play a vital role in the progression of liver cancer, although exact factors and related mechanisms still remain unclear. The present study aimed at screening inflammatory factors related to liver cancer metastasis and investigating the potential mechanism by which cancer cells are recruited. We screened and validated inflammatory factors by microarray and RT-PCR. Small interfering RNA (siRNA) and recombinant protein were used to assess CXCL5 effects on the movement of liver cancer cells (LCCs). Our screening microarray demonstrated over-expression of CXCL5 in LCCs with high metastatic potentials. CXCL5 increased LCCs migration and invasion, probably through autocrine and paracrine mechanisms. CXCL5-CXCR2 and ERK1/2 pathways could play critical roles in the regulation of LCCs migration. Our data indicates that LCCs per se may act as the producer and receptor of CXCL5 responsible for liver cancer migration and invasion.
Highlights
Primary liver cancer is the fifth most common malignancy and the third commonest cause of cancer mortality [1,2]
The present study mapped out the mRNA expression of multiple inflammatory factors/receptors and demonstrated that SPP1 and CXCL5 were highly over-expressed in liver cancer cells (LCCs) with high metastatic potentials
The present study demonstrated that CXC chemokines with sequence Glu-Leu-Arg (ELR motif) were overexpressed in LCCs with high metastatic potentials, such as
Summary
Primary liver cancer is the fifth most common malignancy and the third commonest cause of cancer mortality [1,2]. Metastasis is one of the main characteristics of primary liver cancer, contributing to a poor 5-year survival rate (
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