Abstract
Chemokines regulate cell migration by binding to specific cell surface G protein-coupled receptors in development, physiology, and immune responses. Particularly in cancer, chemokines are involved in tumor cell growth, angiogenesis, cancer stem-like cell properties, metastasis, and directly and indirectly influencing tumor immunity and cancer progression. The chemokine signature in the tumor microenvironment affects immune contexture in tumor tissues and mutual communication between cells through the specific chemokine axis, contributing to cancer prognosis. The present chapter summarizes the role of chemokines in the tumor microenvironment in breast cancer, of which subtypes are classified as luminal A, luminal B, HER2-enriched, and basal-like, focusing on expression levels of chemokines and overall survivals in a chemokine-dependent manner and discovering the target chemokine axis. The outcome provides valuable information that improves the quality of life in patients with breast cancer by supporting the treatment options via the chemokine network in the tumor microenvironment.
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