Roles of cADPR and NAADP in pancreatic beta cell signaling

Abstract

Since the discovery of the pyridine nucleotide metabolites Ca2+ mobilizing messengers cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), they have been demonstrated to function as Ca2+ signaling messengers in a wide range of cell types. In this review, I will briefly summarize the roles of cADPR and NAADP in the physiological process of stimulus-secretion coupling in pancreatic β cells. I am also going to outline the current breadth of knowledge regarding intracellular Ca2+ stores and Ca2+ channels targeted by cADPR and NAADP, as well as the biogenesis of these Ca2+ signaling messengers. I focused on receptor-mediated Ca2+ signaling in mediating the effects of GLP-1 and insulin in pancreatic β cells. A better grasp in the roles of these signaling messengers will assist in our understanding of Ca2+ signaling as well as pathophysiology.