Abstract
Objective To investigate the effects of vortioxetine on BDNF/TrkB signal pathway. Methods Kunming mice were randomized into control group and chronic unpredictable mild stress (CUMS) group. After establishment of depressive models verified by sucrose preference test, the mice in CUMS group were divided into model group and vortioxetine group. The antidepressant effect of vortioxetine was analyzed by Y-maze test, forced swim test and open field test. The expressions of brain-derived neurotrophic factor (BDNF) and TrkB were evaluated with Western blotting. Results Vortioxetine significantly shortened the immobility time of the depressive mice in forced swim test without affecting the locomotor activity of the mice in open fields, suggesting the antidepressant effect of against depression in mice. Vortioxetine significantly improved the depression-like behavior. Vortioxetine significantly increased the expression of BDNF in the hippocampus of the mice (p < 0.01). Conclusion Vortioxetine improves the behaviors of mice with depression possibly by affecting the BDNF/TrkB signal pathway.
Highlights
Depression has developed into a global health problem that seriously affects the physical and mental health of people in all countries and in all social classes.[1]
8.1 Behavior The results shown in Figure1, chronic unpredictable mild stress (CUMS) group compared with the normal control group, the degree of preference for sugar was significantly reduced (p < 0.01), indicating that the experiment model of depression in animal models of success
Forced swimming test is a behavioral despair test for evaluating mice's desire to survive.[13]. The results of this experiment show that the CUMS + K252α group, the CUMS + K252α group and the CUMS group have a significantly lower preference for sugar water in the sugar water test, the immobility time in the forced swimming test (FST) increases significantly, and the residence time in the M-arm in the Y-maze
Summary
Depression has developed into a global health problem that seriously affects the physical and mental health of people in all countries and in all social classes.[1]. [4, 5]Studies have found that classic 5-HT drugs such as fluoxetine in addition to increase the role of 5-HT in the synaptic gap play an antidepressant effect can repair the damaged BDNF/TrkB signaling pathway to promote neuronal growth and development to improve depression symptom.[6] BDNF plays an important role in the process of neuronal growth, survival and differentiation.[7] Abnormal BDNF can cause depression-anxiety-like symptoms.[8] Vortioxetine is a new multi-modal anti-depressant drug used to treat depression in 2013 in Europe and the United States. Vortioxetine can exert antidepressant effect by regulating 5-HT system, but its downstream events are still unclear. It is unclear which signal pathways exert antidepressant effect.
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