Roles and mechanisms of early blood-brain barrier damage in hemorrhagic transformation in acute ischemic stroke after tPA thrombolysis

Ting Wang ,Ke Yang ,Yuan Zhang

doi:10.3760/cma.j.issn.1673-4165.2016.11.010

Roles and mechanisms of early blood-brain barrier damage in hemorrhagic transformation in acute ischemic stroke after tPA thrombolysis

Ting Wang , Ke Yang + Show 1 more

https://doi.org/10.3760/cma.j.issn.1673-4165.2016.11.010

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Publication Date: Nov 28, 2016

Affiliation: Shenzhen Second People's Hospital, Baotou Medical College

#tPA Thrombolysis #Hemorrhagic Transformation + Show 8 more

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Abstract

Hemorrhagic transformation (HT) is the most severe complication after tissue-type plasminogen activator (tPA) thrombolysis. It greatly limits the clinical application of tPA. Early blood-brain barrier (BBB) damage may be an important mechanism for HT. Maintaining the integrity of BBB can significantly decrease the risk of HT. This article reviews the roles, mechanisms, and preventive measure of early BBB damage in HT after tPA thrombolysis. Key words: Stroke; Brain Ischemia; Cerebral Hemorrhage; Blood-Brain Barrier; Tissue Plasminogen Activator; Thrombolytic Therapy

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