Abstract
9099 Background: Psychological distress is high in breast cancer patients with metastases and affects their circadian rhythms of sleep and stress hormones. Yoga as a stress reduction and mind-body intervention is increasingly becoming popular among cancer patients globally. In this study we evaluate the effects of an integrated yoga program vs. supportive therapy on these psychoimmune and endocrine outcomes. Methods: Sixty-Six breast cancer survivors with metastatic disease and adequate performance status (Zubrods 0-2) were recruited and randomized to receive yoga or supportive therapy for a period of12 weeks. Subjects completed Pittsburg Insomnia Rating Scale and Fatigue symptom inventory before and after intervention. Diurnal saliva samples were collected and assessed for cortisol (am and pm) using enzyme Immune assay and morning blood samples for Natural killer cell counts determined by flow cytometry before and after intervention. Results: ANCOVA done with respective baseline measure as a covariate be...
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