Role of WISP1 in diabetes mellitus

Abstract

Wnt1 inducible signaling pathway protein 1(WISP1) is a novel metabolic adipokine, which belongs to secretory glycoprotein and participates in many cell signaling pathways. On the one hand, WISP1 significantly induces inflammation by phosphorylating c-Jun N-terminal kinase (JNK)inflammation signaling pathway; on the other hand, WISP1 impairs the effects of insulin by inhibiting insulin signaling pathway and glycogen synthase kinase phosphorylation. Moreover, WISP1 promotes adipogenesis and the accumulation of triglyceride through bone morphogenetic protein-dependent signaling pathway. It has been reported that serum WISP1 level was significantly increased in diabetic patients. It was confirmed that the decrease of WISP1 could improve inflammation and glucose tolerance, and reduce insulin resistance in mice by vitro and vivo experiments. Therefore, WISP1 is involved in the regulation of inflammation, blood sugar and insulin resistance, which is closely related to the occurrence of diabetes mellitus and is expected to become a biomarker of diabetes mellitus. Key words: WISP1; Diabetes mellitus; Biological markers; Inflammation; Insulin resistance