Abstract
Taurine, a compound present in the tissues of all animals, is known to arise from cystAneas well as through the utilization of sulfate-sulfur. Sulfate, activated by the action of ATP-sulfurylase (EC 2.7.7.4) to form adenc- sinephosphosulfate (APS) and APS-kinase (EC 2.7.1.25) to form 3'-phospho- adenosine-5'-phosphosulfate (PAPS), is then transferred to a carbon acceptor by the action of a sulfotransferase (EC 2.8.2). This enzymatic pathway in vita min-deficient and control chicks was investigated to ascertain the role that vita- min-coenzymes may play in these reactions. Chicks were fed diets deficient in thiamin, riboflavin, vitamin B6,folie acid, vitamin A or vitamin Ds and the sulfate activation and sulfotransferase activities of these birds were assayed. Folie acid- and vitamin A-deficient chicks had lower ATP-sulfurylase and APS-kinase activity than the control birds. Pyridoxine was associated with sulfotransferase activity as evidenced by decreased in vitro taurine formation from PAPS. Vitamin D8- deficient chicks showed a lower rate of taurine synthesis in the liver when ad ministered 35SO4 orally, whereas no difference was observed in taurine synthesis or PAPS formation in vitro. J. Nutr. 102: 313-318, 1972.
Published Version
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