Role of vitamin D supplementation in dental implant osseointegration

Abstract

Successful osseointegration is one of the key criteria for a prosperous dental implant therapy which is achieved by a functional ankylosis. Vitamin D regulates the bone metabolism and bone mineralization by activating osteoclasts and osteoblasts. The effect of vitamin D coated implants on the osseointegration remains controversial. Only slight evidence supports the hypothesis that humans similarly benefit from vitamin D supplementation in terms of osseointegration. The supplementation of vitamin D appears to improve the osseointegration in animals with systemic diseases, such as vitamin D deficiency, diabetes mellitus, osteoporosis, and CKD. Slight evidence supports the hypothesis that humans similarly benefit from vitamin D supplementation in terms of osseointegration.