Role of vitamin D, interleukin-17A and interleukin-10 levels in women with recurrent miscarriage

Abstract

Background: RPL is a common early pregnancy complication that is characterized as three or more pregnancy losses occurring before the 20th week of gestation. RPL is a common early pregnancy complication that is characterized as three or more pregnancy losses occurring before the 20th week of gestation. Recurrent miscarriage (RM) is a common occurrence, affecting 15–25% of all pregnancies. The study's goal was to assess vitamin D, interleukin-17a, and interleukin-10 levels in women who had several miscarriages and investigate the relationship between biomarkers to determine the final outcome of pregnancy. Methods: A case control study that included three study groups; thirty five women with RPL, thirty non-aborted pregnant (NAP) women and twenty five apparently healthy women. Patients were selected from those attending Bint Al-Huda Teaching Hospital and Suq Al-Shuyukh General Hospital at Thi-Qar Province (Iraq) during the period between October 2021 and July 2022 after stringent application of the eligibility criteria. Serum samples was collected form each subjects and was evaluated for serum VD, IL-17A and IL-10 levels via enzyme-linked immunosorbent assay (ELISA). Results: The results revealed that serum VD and IL-10 levels in the RPL group were significantly lower than in the healthy control group (HC).