Abstract
Background and Objective:Chronic obstructive pulmonary disease (COPD) is characterized by chronic incompletely reversible poor airflow and air trapping and usually this debilitating disorder limits the outside activities of the patients depriving them of sunlight which is a rich source of Vitamin D. The objective of this study was to determine the effect of vitamin D supplementation in reducing number of acute exacerbation in COPD patients.Methods:This randomized control trial was conducted at East Medical Ward Mayo Hospital Lahore from January to December 2015 as exacerbations of COPD are season dependent. Diagnosis was confirmed by performing Pulmonary Function Tests (PFTs). Basic demographical information was obtained and baseline PFTs of the patient was done. Only Group A patients was treated with oral vitamin D intake of 2000 IU daily for 6 months. Vitamin D level was measured at 0, 2, 4, and 6 months and exacerbation of COPD, FEV1 and FVC was measured weekly. Both the groups were given standard treatment for exacerbation of COPD. Spirometry was repeated at each visit. Blood samples were collected every 2 months for vitamin D. Supplementation was stopped if vitamin D level exceeded 100ng/ml.Results:The mean age of the patients was 46.28±8.83 years, the male to female ratio was 1.8:1. The mean 25(OH) level at baseline was 24.08±2.58 and at 6th month was 29.60±8.74. The mean FVC at baseline was 77.83±5.49 and at 6th month was 91.34±5.52. The exacerbation at baseline was present in all 120(100%) patients and at 6th month was reduced to 4(3.3%).Conclusion:Vitamin D supplementation has significant effect in reducing number of acute exacerbation in COPD patients when it is given for prolonged period.
Highlights
The main reason for Vitamin D deficiency is lack of ultraviolet-B radiation from less sun contact, Correspondence: January 21, 2017 January 24, 2017 March 31, 2017 April 15, 2017 and this result in lack of vitamin D production in skin
The study results showed that the mean value of forced vital capacity (FVC) at baseline was 77.83±5.49, its mean value at 2nd month was 89.75±7.77, at 4th month its mean value was 89.75±7.77 and its mean value at 6th month was 91.34±5.52
In our study the dyspnea at baseline was present in 96(80%) patients, at 2nd month it was present in 96(80%) patients, at 4th month it was present in 91(75.8%) patients and at 6th month it was present in 87(72.5%) patients
Summary
The main reason for Vitamin D deficiency is lack of ultraviolet-B radiation from less sun contact, Correspondence: January 21, 2017 January 24, 2017 March 31, 2017 April 15, 2017 and this result in lack of vitamin D production in skin. Control of respiratory tract infection through correction of vitamin D level may result in better outcome in patients with Chronic obstructive pulmonary disease (COPD).[5]. The objective of this study was to determine the effect of vitamin D supplementation in reducing number of acute exacerbation in COPD patients. Vitamin D level was measured at 0, 2, 4, and 6 months and exacerbation of COPD, FEV1 and FVC was measured weekly. Both the groups were given standard treatment for exacerbation of COPD. Conclusion: Vitamin D supplementation has significant effect in reducing number of acute exacerbation in COPD patients when it is given for prolonged period
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